Article

Regulation of transcription patterns, poly-ADP-ribose, and RNA-DNA hybrids by the ATM protein kinase

2023-12-07

Abstract excerpt

<h4>Summary</h4> The ATM protein kinase is a master regulator of the DNA damage response and also an important sensor of oxidative stress. Analysis of gene expression in Ataxia-telangiectasia patient brain tissue shows that large-scale transcriptional changes occur in patient cerebellum that correlate with expression level and GC content of transcribed genes. In human neuron-like cells in culture we map locations...

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Literature Corpus work: 332710d3-425c-5c55-8db8-22291419760a
DOI: 10.1101/2023.12.06.570417

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