Article

Virus-derived peptide inhibitors of the herpes simplex virus type 1 nuclear egress complex

2020-06-24

Abstract excerpt

Herpesviruses infect a majority of the human population, establishing lifelong latent infections for which there is no cure. Periodic viral reactivation spreads infection to new hosts while causing various disease states particularly detrimental in the immunocompromised. Efficient viral replication, and ultimately the spread of infection, is dependent on the nuclear egress complex (NEC), a conserved viral heterodi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d5f8a84b-421b-55b1-b1c5-1103eda4c64b
DOI: 10.1101/2020.06.24.168898

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Virus-derived peptide inhibitors of the herpes simplex virus type 1 nuclear egress complexDOI 10.1101/2020.06.24.168898Read

Virus-derived peptide inhibitors of the herpes simplex virus type 1 nuclear egress complex.Semantic proximity Read

Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication.Semantic proximity Read

Escape of herpesviruses from the nucleusSemantic proximity Read

RNA helicase DDX3X modulates herpes simplex virus 1 nuclear egressSemantic proximity Read

Nuclear Egress of HerpesvirusesSemantic proximity Read

Dynamic bulge nucleotides in the KSHV PAN ENE triple helix provide a unique binding platform for small molecule ligandsSemantic proximity Read

The human cytomegalovirus nuclear egress complex unites multiple functions: Recruitment of effectors, nuclear envelope rearrangement, and docking to nuclear capsidsSemantic proximity Read

Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain.Semantic proximity Read

Pressurized DNA state inside herpes capsids—A novel antiviral targetSemantic proximity Read

DNA encapsidation as a target for anti-herpesvirus drug therapy.Semantic proximity Read

Controlled protein activities with viral proteases, antiviral peptides, and antiviral drugsSemantic proximity Read

Mutational Functional Analysis of the Pseudorabies Virus Nuclear Egress Complex-Nucleocapsid Interaction.Semantic proximity Read