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Article

RNA helicase DDX3X modulates herpes simplex virus 1 nuclear egress

1 Feb 2023

Abstract excerpt

DDX3X is a mammalian RNA helicase that regulates RNA metabolism, cancers, innate immunity and several RNA viruses. We discovered that herpes simplex virus 1, a nuclear DNA replicating virus, redirects DDX3X to the nuclear envelope where it surprisingly modulates the exit of newly assembled viral particles. DDX3X depletion also leads to an accumulation of virions in intranuclear herniations. Mechanistically, we...

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PMID: 36725983
DOI: 10.1038/s42003-023-04522-w

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