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Article

Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 2015

Leigh Kendra E, Sharma Mayuri, Mansueto My Sam, Boeszoermenyi Andras, Filman David J, Hogle James M, Wagner Gerhard, Coen Donald M, Arthanari Haribabu

Abstract excerpt

Herpesviruses require a nuclear egress complex (NEC) for efficient transit of nucleocapsids from the nucleus to the cytoplasm. The NEC orchestrates multiple steps during herpesvirus nuclear egress, including disruption of nuclear lamina and particle budding through the inner nuclear membrane. In the important human pathogen human cytomegalovirus (HCMV), this complex consists of nuclear membrane protein UL50, and...

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Identifiers

PMID: 26150520
DOI: 10.1073/pnas.1511140112
PMCID: PMC4517201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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