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Article

Pressurized DNA state inside herpes capsids—A novel antiviral target

23 Jul 2020

Abstract excerpt

Drug resistance in viruses represents one of the major challenges of healthcare. As part of an effort to provide a treatment that avoids the possibility of drug resistance, we discovered a novel mechanism of action (MOA) and specific compounds to treat all nine human herpesviruses and animal herpesviruses. The novel MOA targets the pressurized genome state in a viral capsid, "turns off" capsid pressure, and...

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PMID: 32702029
DOI: 10.1371/journal.ppat.1008604

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