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Article

Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain.

Proceedings of the National Academy of Sciences of the United States of America - 14 Sept 2010

Nadal Marta, Mas Philippe J, Mas Phillipe J, Blanco Alexandre G, Arnan Carme, Solà Maria, Hart Darren J, Coll Miquel

Abstract excerpt

During viral replication, herpesviruses package their DNA into the procapsid by means of the terminase protein complex. In human cytomegalovirus (herpesvirus 5), the terminase is composed of subunits UL89 and UL56. UL89 cleaves the long DNA concatemers into unit-length genomes of appropriate length for encapsidation. We used ESPRIT, a high-throughput screening method, to identify a soluble purifiable fragment of...

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Source

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Identifiers

PMID: 20805464
DOI: 10.1073/pnas.1007144107
PMCID: PMC2941324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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