Article

Spatial drug asymmetry modulates phenotypic diversity-migration relationships under resistance evolution

2024-12-17

Abstract excerpt

At long timescales, resistant phenotypes will emerge and be selected within the bacterial population as an evolutionary response to drug exposure. This phenomenon reduces the efficacy of drug therapies and thus compromises patient health. In spatially heterogeneous drug environments, recent evidence shows that migration can either promote or decelerate the evolution of antibiotic resistance, thereby affecting...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d5f794e0-226d-5e78-b4f6-6ba1491518f8
DOI: 10.1101/2024.12.16.628583

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial drug asymmetry modulates phenotypic diversity-migration relationships under resistance evolutionDOI 10.1101/2024.12.16.628583Read

Determinants of Genetic Diversity of Spontaneous Drug Resistance in Bacteria.Semantic proximity Read

On the rapidity of antibiotic resistance evolution facilitated by a concentration gradientSemantic proximity Read

Bacterial heteroresistance mechanisms, dynamics, and emerging diagnostic approaches.Semantic proximity Read

Heterogeneity in microbial antibiotic responses: genetic basis and within-host evolution.Semantic proximity Read

Bacterial motility governs the evolution of antibiotic resistance in spatially heterogeneous environmentsSemantic proximity Read

Phenotypic Heterogeneity Facilitates Survival While Hindering the Evolution of Drug Resistance Due to Intraspecific CompetitionSemantic proximity Read

Cryptic Evolution of Heteroresistance as Adaptation to Treatment InterruptionsSemantic proximity Read

Environmental heterogeneity facilitates competitive suppression of drug resistanceSemantic proximity Read

Tuning Spatial Profiles of Selection Pressure to Modulate the Evolution of Drug Resistance.Semantic proximity Read

Microbial phenotypic heterogeneity and antibiotic tolerance.Semantic proximity Read

Non-genetic resistance facilitates survival while hindering the evolution of drug resistance due to intraspecific competition.Semantic proximity Read

Phenotypic heterogeneity in bacteria: the rise of antibiotic persistence, clinical implications, and therapeutic opportunities.Semantic proximity Read