Purkinje cell development and degeneration in the spastic Han-Wistar rat model of ataxia

Abstract excerpt

Hereditary ataxia is a neurodegenerative disorder notable for its early onset, with symptoms appearing in patients as young as two years old. Although affected individuals exhibit severe motor deficits and early mortality rates, the timeline of Purkinje cell loss remains unclear. To address this gap, we used the spastic Han-Wistar rat model, which harbors an unknown homozygous recessive variant that causes Purkinj...

Topics

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• Adolescent
• Genes, Dominant
• Genetic Neurodegenerative Diseases
• Intellectual Disability
• Mitochondrial Function and Pathology
• Pedigree
• Spastic Paraplegia, Hereditary
• Spinocerebellar Ataxias

Identifiers and source

Literature Corpus work

d5ec355b-ed1e-5652-b24f-018814bd42d6

DOI

10.1101/2025.09.23.677887