Article

Purkinje cell development and degeneration in the spastic Han-Wistar rat model of ataxia

2025-10-27

Abstract excerpt

<title>Abstract</title> <p>Hereditary ataxia is a neurodegenerative disorder notable for its early onset, with symptoms appearing in patients as young as two years old. Although affected individuals exhibit severe motor deficits and early mortality rates, the timeline of Purkinje cell loss remains unclear. To address this gap, we used the spastic Han-Wistar rat model, which harbors an unknown homozygous recessive...

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Literature Corpus work: 2936accc-ffb9-57f7-b71c-5fa018359ce5
DOI: 10.21203/rs.3.rs-7706512/v1

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