Article
Spatial and temporal pattern of Purkinje cell degeneration in shaker mutant rats with hereditary cerebellar ataxia.
The Journal of comparative neurology - 15 May 1995
Tolbert D L, Ewald M, Gutting J, La Regina M C
Abstract excerpt
Temporal-spatial patterns of surviving Purkinje cells were studied quantitatively in a rat mutant (shaker) with differential hereditary cerebellar ataxia and Purkinje cell degeneration. Shaker rat mutants are characterized behaviorally as mild if they are ataxic or as strong if they have ataxia a...
Topics
- Animals
- Axons
- Behavior, Animal
- Benzoxazines
- Calbindins
- Cerebellar Ataxia
- Dendrites
- Image Processing, Computer-Assisted
- Immunohistochemistry
- Mutation
- Nerve Degeneration
- Nerve Tissue Proteins
- Oxazines
- Purkinje Cells
- Rats
- Rats, Mutant Strains
- Rats, Sprague-Dawley
- S100 Calcium Binding Protein G