Article

Loss of intracerebellar heterogeneity and selective vulnerability in Spinocerebellar ataxia type 1 neurodegeneration

2022-02-25

Abstract excerpt

Regional heterogeneity of neurons and glia is a key feature of the brain, yet the effect of disease on heterogeneity and its relationship with selective neuronal vulnerability remains poorly understood. Using region-specific RNA sequencing, we identified a large number of differentially expressed genes (DEGs) across distinct regions of the cerebellar cortex, supporting the notable intrinsic regional transcriptiona...

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Literature Corpus work: 3dfa1e0a-6bb1-59b5-9d6a-07326f9474c8
DOI: 10.1101/2022.02.24.481789

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