Article
X-linked transmission of the shaker mutation in rats with hereditary Purkinje cell degeneration and ataxia.
Brain research - 10 Mar 2000
Clark B R, LaRegina M, Tolbert D L
Abstract excerpt
This study reports on the mode of inheritance of the shaker mutation and the development of an inbred strain of the shaker rat mutation from Sprague Dawley outbred stock onto a Wistar Furth background. Neuroanatomical and behavioral expression of the affected phenotype, through seven generations of backcross and intercross breeding, has confirmed the mode of inheritance to be X-linked. Behaviorally, affected...
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