Article

Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression

2018-07-30

Abstract excerpt

The impact of mitochondria in epigenetics is emerging but our understanding of this relationship and its impact on gene expression remain incomplete. We previously showed that acute mitochondrial DNA (mtDNA) loss leads to histone hypoacetylation. It remains to be defined if these changes are maintained when mitochondrial dysfunction is chronic and, importantly, if they are sufficient to alter gene expression. To f...

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Literature Corpus work: d5dd9027-3b9e-5762-aae3-37e7090bbc67
DOI: 10.1101/380261

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