Article
Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes.
Molecular cell - 2 Jun 2016
Etchegaray Jean-Pierre, Mostoslavsky Raul
Abstract excerpt
The physiological identity of every cell is maintained by highly specific transcriptional networks that establish a coherent molecular program that is in tune with nutritional conditions. The regulation of cell-specific transcriptional networks is accomplished by an epigenetic program via chromatin-modifying enzymes, whose activity is directly dependent on metabolites such as acetyl-coenzyme A,...
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