Article

Investigation of the use of histone deacetylase inhibitors for the treatment of inherited disorders of the glycolytic pathway

2014-01-01

Abstract excerpt

Histone acetylation by histone acetyltransferases (HATs) and deacetylation by histone deacetylases (HDACs) regulate gene expression by activating or repressing transcription, respectively. HDAC inhibitors (HDACIs) are a diverse class of drugs used to treat haemoglobinopathies, urea cycle disorders and several types of malignancies. Recent evidence from genome-wide as well as gene-specific epigenetic studies sugges...

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Literature Corpus work: 1e355d93-afe2-5c38-8712-d54d75cfba8b
DOI: 10.25560/24822

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