Article

Leveraging family history data to disentangle time-varying effects on disease risk using lifecourse Mendelian randomization

2022-12-20

Abstract excerpt

<title>Abstract</title> <p>Lifecourse Mendelian randomization is a causal inference technique which harnesses genetic variants with time-varying effects to develop insight into the influence of age-dependent lifestyle factors on disease risk. Here, we apply this approach to evaluate whether childhood adiposity has a direct consequence on 8 major disease endpoints by analysing data on first-degree relatives from t...

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Literature Corpus work: d5c7dad5-5337-54b6-9f8f-153dfe7fc14a
DOI: 10.21203/rs.3.rs-1862835/v1

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