Article

DNA damage drives antigen diversification through mosaic Variant Surface Glycoprotein (VSG) formation in <i>Trypanosoma brucei</i>

2024-03-22

Abstract excerpt

<h4>Summary</h4> Antigenic variation, using large genomic repertoires of antigen-encoding genes, allows pathogens to evade host antibody. Many pathogens, including the African trypanosome Trypanosoma brucei, extend their antigenic repertoire through genomic diversification. While evidence suggests that T. brucei depends on the generation of new variant surface glycoprotein (VSG) genes to maintain a chronic infe...

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Literature Corpus work: b1f76a5c-af9c-5cca-8873-f81cf7a81650
DOI: 10.1101/2024.03.22.582209

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