Article

Characterizing Primary transcriptional responses to short term heat shock in paired fraternal lymphoblastoid lines with and without Down syndrome

2023-01-20

Abstract excerpt

Heat shock stress induces genome wide changes in transcription regulation, activating a coordinated cellular response to enable survival. Using publicly available transcriptomic and proteomic data sets comparing individuals with and without trisomy 21, we noticed many heat shock genes are up-regulated in blood samples from individuals with trisomy 21. Yet no major heat shock response regulating transcription facto...

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Literature Corpus work: b6eac7ce-9ca5-50d1-b3d5-a37cb1e7c50e
DOI: 10.1101/2023.01.17.524431

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