Article

Murine Leukemia Virus GlycoGag Antagonizes SERINC5 via ER-phagy Receptor RETREG1

2025-03-06

Abstract excerpt

<h4>ABSTRACT</h4> Serine incorporator 5 (SERINC5) is a host restriction factor that targets certain enveloped viruses, including human immunodeficiency virus type 1 (HIV-1) and murine leukemia virus (MLV). It integrates into the viral envelope from the cell surface, inhibiting viral entry. SERINC5 is transported to the cell surface via polyubiquitination, while a single K130R mutation retains it in the cytoplasm....

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Literature Corpus work: b268004e-b35f-5320-bce7-ce433d8d5784
DOI: 10.1101/2025.03.06.641798

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