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SERINC5 Potently Restricts Retrovirus Infection In Vivo

13 Jul 2020

Abstract excerpt

This study examined for the first time the in vivo function of the ser ine inc orporator (SERINC) proteins during retrovirus infection. SERINC3 and SERINC5 (SERINC3/5) restrict a number of retroviruses, including human immunodeficiency virus 1 (HIV-1) and murine leukemia virus (MLV), by blocking their entry into cells. Nevertheless, HIV-1 and MLV encode factors, Nef and glycosylated Gag, respectively, that...

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PMID: 32665269
DOI: 10.1128/mbio.00588-20

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SERINC5 Potently Restricts Retrovirus Infection In VivoPMID 32665269Read ↗

SERINC5 potently restricts retrovirus infection <i>in vivo</i>Semantic proximity Read ↗

SERINC5 as a New Restriction Factor for Human Immunodeficiency Virus and Murine Leukemia VirusSemantic proximity Read ↗

SERINC5 Is the Primary Target of Retroviral Antagonists Among Human SERINC Paralogs and Requires a Tri-Cysteine Motif for Its Counteraction by HIV-1 NefSemantic proximity Read ↗

Proteasomal degradation of human SERINC4: a potent host anti-HIV-1 factor that is antagonized by NefSemantic proximity Read ↗

The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor.Semantic proximity Read ↗

Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5Semantic proximity Read ↗

Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5Semantic proximity Read ↗

Aromatic Side Chain at Position 412 of SERINC5 Exerts Restriction Activity toward HIV-1 and Other Retroviruses.Semantic proximity Read ↗

The retroviral accessory proteins S2, Nef, and glycoMA use similar mechanisms for antagonizing the host restriction factor SERINC5Semantic proximity Read ↗

CD4 Expression and Env Conformation Are Critical for HIV-1 Restriction by SERINC5Semantic proximity Read ↗

Restriction of Influenza A Virus by SERINC5Semantic proximity Read ↗

Murine Leukemia Virus GlycoGag Antagonizes SERINC5 via ER-phagy Receptor RETREG1Semantic proximity Read ↗

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