Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SERINC5 as a New Restriction Factor for Human Immunodeficiency Virus and Murine Leukemia Virus

28 Sept 2018

Abstract excerpt

SERINC genes encode for homologous multipass transmembrane proteins with unknown cellular function, despite being highly conserved across eukaryotes. Among the five SERINC genes found in humans, SERINC5 was shown to act as a powerful inhibitor of retroviruses. It is efficiently incorporated into virions and blocks the penetration of the viral core into target cells, by impairing the fusion process with a yet...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30265629
DOI: 10.1146/annurev-virology-092917-043308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SERINC5 as a New Restriction Factor for Human Immunodeficiency Virus and Murine Leukemia VirusPMID 30265629Read ↗

SERINC5 Is the Primary Target of Retroviral Antagonists Among Human SERINC Paralogs and Requires a Tri-Cysteine Motif for Its Counteraction by HIV-1 NefSemantic proximity Read ↗

SERINC5 Potently Restricts Retrovirus Infection In VivoSemantic proximity Read ↗

The retroviral accessory proteins S2, Nef, and glycoMA use similar mechanisms for antagonizing the host restriction factor SERINC5Semantic proximity Read ↗

CD4 Expression and Env Conformation Are Critical for HIV-1 Restriction by SERINC5Semantic proximity Read ↗

Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5Semantic proximity Read ↗

Proteasomal degradation of human SERINC4: a potent host anti-HIV-1 factor that is antagonized by NefSemantic proximity Read ↗

Influence of different glycoproteins and of the virion core on SERINC5 antiviral activitySemantic proximity Read ↗

The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor.Semantic proximity Read ↗

Aromatic Side Chain at Position 412 of SERINC5 Exerts Restriction Activity toward HIV-1 and Other Retroviruses.Semantic proximity Read ↗

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissueSemantic proximity Read ↗

SERINC5 potently restricts retrovirus infection <i>in vivo</i>Semantic proximity Read ↗

A Conserved Acidic-Cluster Motif in SERINC5 Confers Partial Resistance to Antagonism by HIV-1 Nef.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.