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Article

Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling.

Cell death & disease - 18 Feb 2020

Ke Minjing, Chong Cheong-Meng, Zeng Haitao, Huang Miaodan, Huang Zhijian, Zhang Ke, Cen Xiaotong, Lu Jia-Hong, Yao Xiaoli, Qin Dajiang, Su Huanxing

Abstract excerpt

The endoplasmic reticulum (ER)-stress-induced cascade events are implicated in Parkinson's disease (PD). The discovery of drug candidates to protect dopaminergic (DA) neurons from ER-stress-induced oxidative damage is important to resolve the pathological aspects of PD and modify its progress. In this study, we found that a recently identified unfolded protein response (UPR) modulator, azoramide, showed...

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Identifiers

PMID: 32071291
DOI: 10.1038/s41419-020-2312-8
PMCID: PMC7028918

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