Article
Review. The endoplasmic reticulum: a target for new anticancer drugs.
In vivo (Athens, Greece) - 1 Jan 2000
Boelens Jerina, Lust Sofie, Offner Fritz, Bracke Marc E, Vanhoecke Barbara W
Abstract excerpt
In eukaryotic cells, the endoplasmic reticulum (ER) is the principal site for the folding and maturation of transmembrane, secretory and ER-resident proteins. Functions of the ER are affected by various intracellular and extracellular stimuli, which include inhibition of glycosylation, reduction of disulfide bonds, calcium depletion from the ER lumen, impairment of protein transport to the Golgi, and expression...
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