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Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4)

27 Nov 2022

Abstract excerpt

Poly- and perfluoroalkyl substances (PFASs) are omnipresent in the environment and have been shown to accumulate in humans. Most PFASs are not biotransformed in animals and humans, so that elimination is largely dependent on non-metabolic clearance via bile and urine. Accumulation of certain PFASs in humans may relate to their reabsorption from the pre-urine by transporter proteins in the proximal tubules of the...

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PMID: 36436016
DOI: 10.1007/s00204-022-03428-6

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