Article

Regulation of mammalian CDC6 by CDK phosphorylation and proteasome dependent degradation

1999-01-01

Abstract excerpt

The mammalian cell cycle is regulated by periodic gene transcription, kinase activities and protein degradation. A human cDNA encoding a protein homologous to <i>S. cerevisiae</i> Cdc6p and <i>S. pombe</i> Cdc18 was identified. Mammalian CDC6 is essential for DNA replication, and the obtained data demonstrate that the mammalian CDC6 protein is regulated by several mechanisms. The subcellular localization of mammal...

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Literature Corpus work: d558ffe8-8893-5928-8fe6-b837a86866d2
DOI: 10.21954/ou.ro.0000ff48

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