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Article

Phosphorylation controls timing of Cdc6p destruction: A biochemical analysis.

Molecular biology of the cell - 1 Oct 1999

Elsasser S, Chi Y, Yang P, Campbell J L

Abstract excerpt

The replication initiation protein Cdc6p forms a tight complex with Cdc28p, specifically with forms of the kinase that are competent to promote replication initiation. We now show that potential sites of Cdc28 phosphorylation in Cdc6p are required for the regulated destruction of Cdc6p that has been shown to occur during the Saccharomyces cerevisiae cell cycle. Analysis of Cdc6p phosphorylation site mutants and...

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Identifiers

PMID: 10512865
DOI: 10.1091/mbc.10.10.3263
PMCID: PMC25589

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