Article
T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system.
Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 2020
Mohan Rajiv A, Bosada Fernanda M, van Weerd Jan H, van Duijvenboden Karel, Wang Jianan, Mommersteeg Mathilda T M, Hooijkaas Ingeborg B, Wakker Vincent, de Gier-de Vries Corrie, Coronel Ruben, Boink Gerard J J, Bakkers Jeroen, Barnett Phil, Boukens Bas J, Christoffels Vincent M
Abstract excerpt
Genome-wide association studies have identified noncoding variants near TBX3 that are associated with PR interval and QRS duration, suggesting that subtle changes in TBX3 expression affect atrioventricular conduction system function. To explore whether and to what extent the atrioventricular conduction system is affected by Tbx3 dose reduction, we first characterized electrophysiological properties and morphology...
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