Diminished PRRX1 Expression Is Associated With Increased Risk of Atrial Fibrillation and Shortening of the Cardiac Action Potential.

doi:10.1161/CIRCGENETICS.117.001902

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Article

Diminished PRRX1 Expression Is Associated With Increased Risk of Atrial Fibrillation and Shortening of the Cardiac Action Potential.

Circulation. Cardiovascular genetics - 1 Oct 2017

Tucker Nathan R, Dolmatova Elena V, Lin Honghuang, Cooper Rebecca R, Ye Jiangchuan, Hucker William J, Jameson Heather S, Parsons Victoria A, Weng Lu-Chen, Mills Robert W, Sinner Moritz F, Imakaev Maxim, Leyton-Mange Jordan, Vlahakes Gus, Benjamin Emelia J, Lunetta Kathryn L, Lubitz Steven A, Mirny Leonid, Milan David J, Ellinor Patrick T

Abstract excerpt

BACKGROUND: Atrial fibrillation (AF) affects over 33 million individuals worldwide. Genome-wide association studies have identified at least 30 AF loci, but the mechanisms through which individual variants lead to altered disease risk have remained unclear for the majority of these loci. At the 1q24 locus, we hypothesized that the transcription factor PRRX1 could be a strong candidate gene as it is expressed in...

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PMID: 28974514
DOI: 10.1161/CIRCGENETICS.117.001902
PMCID: PMC5679717

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PRRX1

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