Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of nemo-like kinase in diamond blackfan anemia suppresses early erythropoiesis by preventing mitochondrial biogenesis

9 Jul 2024

Abstract excerpt

Diamond Blackfan Anemia (DBA) is a rare macrocytic red blood cell aplasia that usually presents within the first year of life. The vast majority of patients carry a mutation in one of approximately 20 genes that results in ribosomal insufficiency with the most significant clinical manifestations being anemia and a predisposition to cancers. Nemo-like Kinase (NLK) is hyperactivated in the erythroid progenitors of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cancer-related gene regulation
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38992436
DOI: 10.1016/j.jbc.2024.107542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of nemo-like kinase in diamond blackfan anemia suppresses early erythropoiesis by preventing mitochondrial biogenesisPMID 38992436Read ↗

Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.Semantic proximity Read ↗

Inhibition of NLRP1 Inflammasome Activation by Tyrosine Kinase Inhibitors Restores Erythropoiesis in Diamond-Blackfan Anemia SyndromeSemantic proximity Read ↗

Oxidative phosphorylation pathway disruption is an alternative pathological mechanism leading to Diamond-Blackfan anemiaSemantic proximity Read ↗

An update on the pathogenesis and diagnosis of Diamond–Blackfan anemiaSemantic proximity Read ↗

Molecular convergence in ex vivo models of Diamond-Blackfan anemia.Semantic proximity Read ↗

Diamond Blackfan anemia 2008-2009: broadening the scope of ribosome biogenesis disorders.Semantic proximity Read ↗

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.Semantic proximity Read ↗

Ancient genomic linkage couples metabolism with erythroid developmentSemantic proximity Read ↗

The multifunctional role of EKLF/KLF1 during erythropoiesis.Semantic proximity Read ↗

RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan anemia through antagonizing lefty1Semantic proximity Read ↗

Autophagy as a Regulatory Component of ErythropoiesisSemantic proximity Read ↗

Diamond-Blackfan anemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.