Article
Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma.
Nature communications - 14 May 2018
North Jeffrey P, Golovato Justin, Vaske Charles J, Sanborn J Zachary, Nguyen Andrew, Wu Wei, Goode Benjamin, Stevers Meredith, McMullen Kevin, Perez White Bethany E, Collisson Eric A, Bloomer Michele, Solomon David A, Benz Stephen C, Cho Raymond J
Abstract excerpt
Sebaceous carcinomas (SeC) are cutaneous malignancies that, in rare cases, metastasize and prove fatal. Here we report whole-exome sequencing on 32 SeC, revealing distinct mutational classes that explain both cancer ontogeny and clinical course. A UV-damage signature predominates in 10/32 samples, while nine show microsatellite instability (MSI) profiles. UV-damage SeC exhibited poorly differentiated,...
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