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Functional antagonism between ΔNp63α and GCM1 regulates human trophoblast stemness and differentiation

25 Mar 2022

Abstract excerpt

The combination of EGF, CHIR99021, A83-01, SB431542, VPA, and Y27632 (EGF/CASVY) facilitates the derivation of trophoblast stem (TS) cells from human blastocysts and first-trimester, but not term, cytotrophoblasts. The mechanism underlying this chemical induction of TS cells remains elusive. Here we demonstrate that the induction efficiency of cytotrophoblast is determined by functional antagonism of the...

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PMID: 35338152
DOI: 10.1038/s41467-022-29312-6

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