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The multifaceted role of GCM1 during trophoblast differentiation in the human placenta

28 Nov 2022

Abstract excerpt

Remodeling of the uterine vasculature by invasive extravillous trophoblasts (EVTs) is a critical aspect of human placentation. Insufficient EVT invasion can lead to severe obstetrical complications like preeclampsia, intrauterine growth restriction, and preterm birth. Glial cells missing-1 (GCM1) is a transcription factor that is crucial for proper placentation in mice, and is highly expressed in human...

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PMID: 36442132
DOI: 10.1073/pnas.2203071119

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