Article

Validated machine learning algorithm with sub-clonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity

2021-05-22

Abstract excerpt

Human leukocyte antigen loss of heterozygosity (HLA LOH) allows cancer cells to escape immune recognition by deleting HLA alleles, causing the suppressed presentation of tumor neoantigens that would otherwise bind to them. Despite its importance in immunotherapy response, few methods exist to detect HLA LOH, and their accuracy is not well understood. Here, we develop DASH ( D eletion of A llele- S pecific H LA...

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Literature Corpus work: d5279dfe-bc11-53c8-aba6-1999f312bfa0
DOI: 10.1101/2021.05.20.445052

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