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Article

Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution.

Cell - 30 Nov 2017

McGranahan Nicholas, Rosenthal Rachel, Hiley Crispin T, Rowan Andrew J, Watkins Thomas B K, Wilson Gareth A, Birkbak Nicolai J, Veeriah Selvaraju, Van Loo Peter, Herrero Javier, Swanton Charles

Abstract excerpt

Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the polymorphic nature of the locus has precluded accurate HLA copy-number analysis. Here, we present loss of heterozygosity in human leukocyte antigen (LOHHLA), a computational tool to determine HLA allele-specific copy number from sequencing data....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29107330
DOI: 10.1016/j.cell.2017.10.001
PMCID: PMC5720478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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