Article

Correlation of receptor density and mRNA expression patterns in the human cerebral cortex

2021-12-23

Abstract excerpt

Changes in distribution of associated molecular targets have been reported across several neuropsychiatric disorders. However, the high-resolution topology of most proteins is unknown and simultaneous in vivo measurement in multi-receptor systems is complicated. To account for the missing proteomic information, mRNA transcripts are typically used as a surrogate. Nonetheless, post-transcriptional and post-translat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d738fbf2-3cc4-5db3-90b3-50359d295dc1
DOI: 10.1101/2021.12.23.473947

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Correlation of receptor density and mRNA expression patterns in the human cerebral cortexDOI 10.1101/2021.12.23.473947Read

Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brainSemantic proximity Read

Imaging transcriptomics: Convergent cellular, transcriptomic, and molecular neuroimaging signatures in the healthy adult human brainSemantic proximity Read

A practical guide to linking brain-wide gene expression and neuroimaging dataSemantic proximity Read

Regional gene expression patterns are associated with task-specific brain activation during reward and emotion processing measured with functional MRISemantic proximity Read

The predictive power of mRNA mapping for Cannabinoid 1 receptor protein in the human brainSemantic proximity Read

Inter-individual variability of neurotransmitter receptor and transporter density in the human brainSemantic proximity Read

How Do Neurotransmitter Pathways Contribute to Neuroimaging Phenotypes?Semantic proximity Read

A spatially-resolved human brain proteome atlas for understanding function and diseaseSemantic proximity Read

Neurochemical and molecular characteristics of altered brain functional activity in the anti-NMDAR encephalitisSemantic proximity Read

Benchmarking macaque brain gene expression for horizontal and vertical translationSemantic proximity Read

Limited predictive power of DAT mRNA mappings for DAT protein expressionsSemantic proximity Read

Brain shuttle target expression levels vary by individual, not by brain region, disease, age, or sexSemantic proximity Read