Article

IRE1α-XBP1 Activation Elicited by Viral Singled Stranded RNA via <i>TLR8</i> May Modulate Lung Cytokine Induction in SARS-CoV-2 Pneumonia

2022-01-28

Abstract excerpt

Initial symptoms of COVID-19 infection depend on viral replication, while hyperinflammation is a hallmark of critical illness and may drive severe pneumonia and death. Among the mechanisms potentially involved in the hyperinflammatory state, we focused on the unfolded protein response, because the IRE1α-XBP1 branch can be activated as result of the endoplasmic reticulum stress produced by the overwhelming synthesi...

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Literature Corpus work: d51b2dae-d3e2-5c8e-bd75-2a9bf0eac0f0
DOI: 10.1101/2022.01.26.22269752

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