Article

Deconstructing evolutionary histories of complex genomic rearrangements in lung malignancies

2024-11-12

Abstract excerpt

Somatic genomic rearrangements are hallmarks of cancer. Complex genomic rearrangements (CGRs) involving multiple intertwined structural alterations are often present in tumor genomes. CGRs frequently harbor oncogenic drivers, but their genomic architectures and etiologies are poorly understood. We used deep-coverage optical mapping technology to profile the genomic landscapes of normal lung tissues, benign pulmona...

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Literature Corpus work: d506a352-41b6-500b-b8d0-2bb78b092cc3
DOI: 10.1101/2024.11.11.623122

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