Article

Whole genome optical mapping reveals multiple fusion events chained by large novel sequences in cancer

2017-07-20

Abstract excerpt

Genomic rearrangements are common in cancer, with demonstrated links to disease progression and treatment response. These rearrangements can be complex, resulting in fusions of multiple chromosomal fragments and generation of derivative chromosomes. While methods exist for detecting individual fusions, they are generally unable to reconstruct complex chained events. To overcome these limitations, we adopted a new...

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Literature Corpus work: fe4dac66-9050-563d-bc48-44b1e091f6ff
DOI: 10.1101/166173

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