Article

Pupillary dilation responses as a midlife indicator of risk for Alzheimer’s Disease: Association with Alzheimer’s disease polygenic risk

2019-05-02

Abstract excerpt

<h4>ABSTRACT</h4> Pathological changes in Alzheimer’s disease (AD) begin decades before dementia onset. Because locus coeruleus tau pathology is the earliest occurring AD pathology, targeting indicators of locus coeruleus (dys)function may improve midlife screening for earlier identification of AD risk. Pupillary responses during cognitive tasks are driven by the locus coeruleus and index cognitive effort. Severa...

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Literature Corpus work: d4e24a3f-58e2-55cf-8e3a-8d3e8a544c49
DOI: 10.1101/624767

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