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Article

Pupillary Responses as a Biomarker of Early Risk for Alzheimer’s Disease

1 Feb 2017

Abstract excerpt

Task-evoked pupillary responses may be a psychophysiological biomarker of early risk for mild cognitive impairment (MCI) and Alzheimer's disease (AD). Pupil dilation during cognitive tasks reflects cognitive effort until compensatory capacity is surpassed and performance declines are manifest, and reflects activation in the locus coeruleus, where degenerative changes have been found in the earliest stages of AD....

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PMID: 28157098
DOI: 10.3233/jad-161078

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