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Locus coeruleus catecholamines link neuroticism and vulnerability to tau pathology in aging

30 Sept 2022

Abstract excerpt

Higher neuroticism is a risk factor for Alzheimer's disease (AD), and is implicated in disordered stress responses. The locus coeruleus (LC)-catecholamine system is activated during perceived threat and is a centerpiece of developing models of the pathophysiology of AD, as it is the first brain region to develop abnormal tau. We examined relationships among the “Big 5” personality traits, LC catecholamine...

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PMID: 36191755
DOI: 10.1016/j.neuroimage.2022.119658

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