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Kidney disease reprograms microbiome-host signaling to promote heart failure

2026-01-12

Abstract excerpt

<h4>Background</h4> Heart failure is prevalent in chronic kidney disease (CKD) and linked to chronic inflammation. CKD-typical gut microbiome dysbiosis may stimulate inflammation, as bacterial aromatic metabolites are highly abundant and engage transcriptional programs through the aryl hydrocarbon receptor (AhR). Whether this axis drives cardiac remodeling and is therapeutically targetable remains unknown. <h4>Me...

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Literature Corpus work
d4cd01d6-c092-58a7-bf03-d81a4bd38e93
DOI
10.64898/2026.01.10.698142
Open publication

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Kidney disease reprograms microbiome-host signaling to promote heart failureDOI 10.64898/2026.01.10.698142
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