Inflammation in children with chronic kidney disease linked to gut dysbiosis and metabolite imbalance

Abstract excerpt

Chronic kidney disease (CKD) is characterized by a sustained pro-inflammatory response. The underlying mechanisms are incompletely understood, but may be linked to gut dysbiosis. Dysbiosis has been described in adults with CKD; however, comorbidities limit CKD-specific conclusions. We analyzed the fecal microbiome, metabolites and immune phenotypes in children at three different CKD stages (G3-G4, G5 (hemodialysis...

Topics

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• Adolescent and Pediatric Healthcare
• Childhood Cancer Survivors' Quality of Life
• Clostridium difficile and Clostridium perfringens research
• Dialysis and Renal Disease Management
• Diet and metabolism studies
• Gastrointestinal motility and disorders
• Gut microbiota and health
• Inflammatory Bowel Disease

Identifiers and source

Literature Corpus work

0e06e69c-d25e-5de7-81b1-b433392df47d

DOI

10.1101/2022.01.21.22269663