Transcriptomic Profiling of Peripheral Blood Mononuclear Cells Reveals Key Molecular Signatures in Chronic Kidney Disease Patients with Heart Failure

Abstract excerpt

<h4>Background</h4> Heart failure (HF) is a frequent and severe complication among patients with chronic kidney disease (CKD), particularly in advanced stages and end stage renal disease (ESRD). This study focuses on understanding the molecular interplay between CKD and HF beyond the context of maintenance hemodialysis (MHD). Given that peripheral blood mononuclear cells (PBMCs) reflect systemic inflammatory and...

Topics

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• Genome-Wide Association Study
• Glomerular Filtration Rate
• Kidney Failure, Chronic
• Polymorphism, Single Nucleotide
• Renal Insufficiency, Chronic
• Sequence Analysis, RNA
• Single-Cell Analysis
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

6cf8c390-1cc1-5b8a-b593-f7e8442ae65b

DOI

10.64898/2025.12.29.25343179