Interleukin-17A Mediates Cardiorenal Injury In Oxalate Nephropathy

Abstract excerpt

<h4>Aims</h4> Cardiovascular disease (CVD) is the leading cause of mortality in chronic kidney disease (CKD). While CKD is known to give rise to systemic inflammation, its inciting factors remain poorly defined. Oxalate, long implicated in rare genetic kidney disorders, accumulates with decreased kidney function and has emerged as a driver of inflammation and independent risk factor for CVD. Here, we investigate...

Topics

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• Inflammasomes
• Carrier Proteins
• Disease Progression
• Inflammation Mediators
• Kidney
• Nephritis
• NLR Family, Pyrin Domain-Containing 3 Protein
• Renal Insufficiency

Identifiers and source

Literature Corpus work

ca231072-975c-5eb6-b200-b00edcef7e26

DOI

10.1101/2025.11.17.687153