Article

The Endothelium Modulates the Prothrombotic Phenotype of Factor V Leiden: Evidence from an Ex Vivo Model

2023-11-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Clinical expressivity of the thrombophilic factor V Leiden (FVL) mutation is highly variable. Increased activated protein C (APC) formation in response to thrombin formation has been observed in asymptomatic FVL carriers in vivo. Here we further explored this association using a recently developed endothelial colony forming cell (ECFC)-based ex-vivo model. <h4>Methods</h4>...

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Literature Corpus work: d4bd2249-3a30-5f21-aa4f-568d84f63550
DOI: 10.1101/2023.11.15.567299

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