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Endothelium-Dependent Protein C Activation in Hereditary Protein C Deficiency.

Thrombosis and haemostasis - 1 Feb 2026

Schwarz Nadine, McRae Hannah L, Reda Sara, Pezeshkpoor Behnaz, Oldenburg Johannes, Müller Jens, Pötzsch Bernd, Rühl Heiko

Abstract excerpt

Protein C (PC) activation on endothelial cells is a critical antithrombotic mechanism. Hereditary PC deficiency (PCD), which is caused by mutations in the PROC gene, can predispose affected individuals to thrombophilia. Previous studies investigated activated protein C (APC) generation in PCD patients without including endothelial cells, which are essential for physiological PC activation. This study aimed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40209762
DOI: 10.1055/a-2579-6390

Genes

APC
PC
PROC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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