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Article

Endothelium Modulates the Prothrombotic Phenotype of Factor V Leiden: Evidence From an Ex Vivo Model.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2025

Schwarz Nadine, Müller Jens, McRae Hannah L, Reda Sara, Pezeshkpoor Behnaz, Oldenburg Johannes, Pötzsch Bernd, Rühl Heiko

Abstract excerpt

BACKGROUND: Clinical expressivity of the thrombophilic factor V Leiden (FVL) mutation is highly variable. Recently, we demonstrated an increased APC (activated protein C) response in asymptomatic FVL carriers compared with FVL carriers with a history of venous thromboembolism (VTE) after in vivo coagulation activation. Here, we further explored this association using a recently developed ex vivo model based on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39846164
DOI: 10.1161/ATVBAHA.124.322116

Genes

APC
TF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Endothelium Modulates the Prothrombotic Phenotype of Factor V Leiden: Evidence From an Ex Vivo Model.PMID 39846164Read ↗

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