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Article

Protein S levels modulate the activated protein C resistance phenotype induced by elevated prothrombin levels.

Thrombosis and haemostasis - 1 Feb 2006

Brugge Jeroen M, Tans Guido, Rosing Jan, Castoldi Elisabetta

Abstract excerpt

Elevated plasma prothrombin levels, due to the prothrombin 20210 G/A mutation or to acquired causes, are a risk factor for venous thrombosis, partly because of prothrombin-mediated inhibition of the protein C anticoagulant pathway and consequent activated protein C (APC) resistance. We determined the effect of plasma prothrombin concentration on the APC resistance phenotype and evaluated the role of protein S...

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Share to Activated Protein C Resistance
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16493484
DOI: 10.1160/TH05-08-0582

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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