Article

Prion Seeding Activity in DNA Extractions: Implications for Laboratory Biosafety

2025-09-17

Abstract excerpt

<h4>ABSTRACT</h4> Infectious prions (PrP Sc ) are largely resistant to proteolytic digestion, including proteinase K digestion. While nucleic acid extracts are generally considered non-infectious, we investigated whether standard DNA purification methods can co-purify PrP Sc , posing an unrecognized biosafety risk. Two laboratories, the University of Minnesota Center for Prion Research and Outreach (MNPRO) and...

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Literature Corpus work: d4b9ef76-0400-508c-a816-2190fffb8216
DOI: 10.1101/2025.09.15.676309

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